Bridge Capture / Technology
Targeted sequencing by Geno1® technologies

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Affordable testing
Bridge Capture™ is engineered for cost-efficiency, utilizing off-the-shelf reagents and optimizing the use of sequencing capacity to minimize test costs.
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Sensitive detection
Bridge Capture™ delivers proven sensitivity, meeting the rigorous demands of even the most challenging oncological applications.
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Portable workflows
Bridge Capture™ is designed for simplicity, portability, and kittability, ensuring seamless adoption in any laboratory setting, effortless usability in distributed environments, and compatibility with any sequencing platform.
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Pan-cancer detection
Bridge Capture™ supports panels of any size, enabling true pan-cancer detection across any number and type of mutations.

Bridge Capture™ is a laboratory process designed for simple, sensitive and cost-efficient targeting of DNA sequencing.
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At the beginning of the process, the probe-bridge complexes are circularized around their genomic targets.
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Linear DNA is degraded, leaving only circularized probes.
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Circular probes are amplified using rolling circle amplification.
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The concatemers are indexed using limited-cycle PCR.
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The circular probes can be directly sequenced on NGS platforms using circular sequencing templates.
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The concatemers can be sequenced on nanopore platforms.
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The PCR-indexed templates can be sequenced on Illumina or Ion Torrent platforms.
How does it perform?

Bridge capture™
Publications
Bridge capture™